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KMID : 0363620080290020133
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Journal of Korean Oriental Medicine
2008 Volume.29 No. 2 p.133 ~ p.150
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Improved Axonal Regeneration Responses in the Injured Sciatic Nerve of Rats by Danggui Treatment
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Hong Soon-Sung
Oh Min-Seok
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Abstract
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Objective: This study was performed to examine Danggui (DG, Angelica gigas Nakai)’s potential activity for
promoting axonal regeneration in the injured peripheral nerve.
Methods: Using the sciatic nerve in the rats, DG extract 5 (10 / in 0.5% saline) was dripped into the injury site of the nerve.
Results: DG treatment facilitated axonal elongation responses in the distal portion to the injury site. GAP-43 protein levels were upregulated by DG treatment in the injured nerve and also in the DRG, suggesting the induction of
GAP-43 expression at gene expression level after nerve injury. Phospho-Erk1/2 protein levels were upregulated in the injured nerve area and also in the DRG, suggesting retrograde transport of phospho-Erk1/2 protein from the injury area to the cell body. Cdc2 protein levels were slightly upregulated by DG treatment. DG treatment increased the number of non-neuronal cells in the distal portion to the injury site.
Conclusions: The present data suggest that DG is effective for enhanced axonal regrowth after sciatic nerve injury.
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KEYWORD
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Danggui (DG, Angelica gigas Nakai), sciatic nerve, axonal regeneration
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